Abstract
Three types of 24-h extended-release multiparticulate capsules containing a dose of 480-504 mg lithium carbonate in a form of either pellets or 2 mm minitablets or 6 mm tablets were prepared. Dissolutions tests were performed using three different pharmacopoeial apparatus: basket, paddle and flow-through apparatus. Only capsules filled with pellets showed the same dissolution profiles, irrespective of the apparatus used in the study. In the case of two other formulations, the slowest dissolution occurred in the flow-through apparatus. The largest difference between release profiles from different apparatus was observed for the capsule filled with 6 mm tablets. The observations may indicate that probability of good reproducibility of dissolution profiles obtained in different test conditions, including change of apparatus, is related to either size or a number of the units in a capsule.
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