Abstract
The application of numerical analysis is suitable for the estimation of rate constant of dissolution and the simulation of dissolution under nonsink conditions. The dissolution rate constants of various particle sizes of methyl-, ethyl-, propyl-, butylparaben were calculated by the numerical analysis, and it was clarified that the product of dissolution rate constant by particle size is nearly equal for all experiments and that the dissolution rate constants do not change under both sink and nonsink conditions. The effects of solubility, nonsink condition, crystal size and crystal shape on dissolution rate were simulated.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
