Abstract
The rate-limiting step in the absorption of poorly watersoluble drugs is often the dissolution process of these compounds. Surface-active agents influence the dissolution process by wetting and solubilizing. In order to study the effect of solubilization, a rotating-disk apparatus was used with griseofulvin as a model drug substance and sodium dodecylsulphate (SDS) as a model surfactant. The dissolution kinetics of griseofulvin in SDS solutions could adequately be described by the convective-diffusion model and the phase-separation model for micellar systems. The calculated micellar diffusion coefficient of SDS was in close agreement with values reported in the literature.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.