Abstract
The crystal behavior, solubilities, and dissolution rates of three crystalline forms of prednisolone were investigated in dilute sodium lauryl sulfate solutions. A solubilization effect was noted at concentrations considerably below the critical micelle concentration. Also, at a concentration of 0.1 per cent sodium lauryl sulfate the release from supersaturation of a metastable anhydrous crystal form was more rapid than in purely aqueous solutions. Substantial dissolution rate increases were observed in the surface-active media. It appeared that these increases could be accounted for by the solubilization effect and an apparent increase in the interfacial reaction rate.
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