Abstract
The dissolution kinetics of benzoic acid has been studied in the presence of certain surface-active agents. The addition of tyloxapol, polysorbate 80, sodium lauryl sulfate, and poloxakol to the dissolving fluid increased the apparent solubility of benzoic acid. In considering the experimentally determined dissolution rate as a function of solubility, it appears that the dissolution process in solutions of tyloxapol, polysorbate 80, and sodium lauryl sulfate concurs with the diffusion layer concept, while the dissolution process in the presence of poloxakol is best described by an interfacial barrier model.
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