Abstract
It is shown that dissolution from constant-surface pellets into micellar solutions follows first-order kinetics in agreement with theory. A method to determine the apparent zero-order rate constant for dissolution from constant-surface preparations, which does not require maintenance of sink conditions, is suggested. Theoretical considerations and experimental data are presented to show that the difference between the dissolution rate of a drug in micellar solution and its dissolution rate in water does not represent the hypothetical dissolution rate of drug into the micellar pseudo phase.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.