Abstract
It is shown that dissolution from constant-surface pellets into micellar solutions follows first-order kinetics in agreement with theory. A method to determine the apparent zero-order rate constant for dissolution from constant-surface preparations, which does not require maintenance of sink conditions, is suggested. Theoretical considerations and experimental data are presented to show that the difference between the dissolution rate of a drug in micellar solution and its dissolution rate in water does not represent the hypothetical dissolution rate of drug into the micellar pseudo phase.
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