Dissolution improvement of binary solid dispersions of Carbamazepine using Poly (2-ethyl-2-oxazoline) as the hydrophilic carrier.

Abstract

Theaim of this study was to design and evaluate the properties of soliddispersions of carbamazepine (CBZ) using poly (2-ethyl-2-oxazoline) (POX) asthe hydrophilic carrier. These binary solid dispersions were prepared at varyingdrug loadings using the solvent evaporation method. The samples were evaluatedfor their in vitro dissolution, and solid-state properties. There was over 350%increase in dissolution rate of CBZ in samples containing at least 50% POX.This study concludes that POX is an effective hydrophilic carrier for poorlysoluble drugs in solid dispersions.