Dissolution Enhancement of Domperidone Using Water Soluble Carrier by Solid Dispersion Technology

Abstract

Domperidone is a highly water insoluble drug exhibiting poor dissolution pattern. This is the cause for its poor absorption. Currently, several products of this drug substance is available in the market. Solid dispersions of domperidone were prepared using different ratios of polyvinylpyrrolidone as carrier by kneading method. They were evaluated for drug content, intactness of the drug in the formulation and dissolution. IR spectral and DSC studies were used to characterize the solid dispersion and to study the possibility of complexation of drug with carrier. The dissolution of domperidone from the solid dispersions exhibited higher rates of dissolution and dissolution efficiency values over that of pure drug