Abstract
The dissolution rate of a crystalline solid dispersion could be influenced by multiple factors including its composition, the form and crystallinity of the containing drug, and its microstructure. In this study, crystalline dispersions of a fast-crystallizing drug, β-lapachone (β-LAP), within the matrix of polyethylene glycol (PEG) or poly(ethylene oxide)–poly(propylene oxide)–poly(ethylene oxide) triblock copolymer (Poloxamer 188), were obtained by spray drying. The drug–polymer interaction, crystallization kinetics of the drug and polymer upon solvent evaporation, and the microstructure of the crystalline dispersion were investigated by various techniques including differential scanning calorimetry, polarized optical microscopy/hot-stage, scanning electron microscopy, wide-angle X-ray diffraction, small-angle X-ray scattering, atomic force microscopy, X-ray photoelectron spectroscopy, etc. The intrinsic dissolution rate of the β-LAP/P188 crystalline dispersion was almost 30 times faster than that of β-L...
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