Abstract
Amorphous calcium phosphate (ACP) is known as one of the precursors of bone hydroxyapatite (HAp). The ACP transforms into low crystalline HAp around 40°C. Zinc (Zn) is an essential trace element for the human body and has an important role in bone formation. Osteoporosis has been linked to Zn deficiency. Biomaterials that release Zn at site of bone resorption can potentially inhibit the progression of osteoporosis. In this study, we successfully prepared Zn-releasing injectable materials that consisting of ACP and alginate gel. We investigated the Zn dissolution behavior from these composite samples in environment that imitate bone metabolism. The Zn containing gel released Zn into an acetic acid buffer, which mimics the environment of osteoclast activity. In contrast, the gel sample did not released Zn when soaked in a simulated body fluid (Kokubo’s solution), a solution that mimics the environment of osteoblast activity and cell quiescence. Therefore, the ACP/alginate gel composite that is cross-linked with Zn2+ could control the rate of release in Zn. These gels are expected to be a Zn controlled-release intelligent material.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
