Abstract
GluA1 AMPA receptor subunit knockout mice display a selective impairment on short-term recognition memory tasks. In this study we tested whether GluA1 is important for short-term memory that is necessary for bridging the discontiguity between cues in trace conditioning. GluA1 knockout mice were not impaired at using short-term memory traces of T-maze floor inserts, made of different materials, to bridge the temporal gap between conditioned stimuli and reinforcement during appetitive discrimination tasks. Thus, different aspects of short-term memory are differentially sensitive to GluA1 deletion. This dissociation may reflect processing of qualitatively different short-term memory traces. Memory that results in performance of short-term recognition (e.g. for objects or places) may be different from the memory required for associative learning in trace conditioning.
Highlights
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The results show that GluA1−/− mice were not impaired on trace conditioning tasks in which they had to maintain a shortterm memory of floor inserts made of different materials in order to obtain reward
They successfully acquired a simple discrimination, with and without additional delays (Experiment 1), and a non-spatial, conditional discrimination, with and without a discontiguity between the start arm conditional cue and the goal arm cues (Experiments 3 and 2, respectively). This contrasts with the impairments in both spatial and non-spatial, short-term recognition memory displayed by GluA1−/− mice [4,5,7,8]
Summary
The full-text may be used and/or reproduced, and given to third parties in any format or medium, without prior permission or charge, for personal research or study, educational, or not-for-prot purposes provided that:. GluA1 AMPA receptor subunit knockout mice display a selective impairment on short-term recognition memory tasks. In this study we tested whether GluA1 is important for short-term memory that is necessary for bridging the discontiguity between cues in trace conditioning. GluA1 knockout mice were not impaired at using short-term memory traces of T-maze floor inserts, made of different materials, to bridge the temporal gap between conditioned stimuli and reinforcement during appetitive discrimination tasks. Different aspects of short-term memory are differentially sensitive to GluA1 deletion. Modified mice lacking the GluA1 AMPA receptor subunit ( referred to as GluA1−/− mice [1]) display impaired short-term memory. It is possible that GluA1 is necessary for short-term maintenance of memory that is necessary for trace conditioning as well as shortterm memory required for discriminating between stimuli on the basis of how recently they have been experienced
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