Abstract
Abstract Zinc excretion was compared with sodium, potassium, calcium, and magnesium during clearance studies in 38 normal men. Base-line zinc excretion (per unit inulin clearance) averaged 44.2 ± 4.1 nEq. per 100 ml., and correlated modestly (r = 0.39) with plasma zinc concentrations. During isotonic saline loading, zinc excretion increased 28 per cent (P decreased 15 per cent while sodium, calcium, and magnesium excretion increased an additional 102, 61, and 33 per cent, respectively. After intravenous furosemide or ethacrynic acid, zinc excretion increased, but rapidly reverted to control values. In contrast, large increases in sodium, calcium, and magnesium excretion were maintained for 2 hours. Urine zinc concentrations decreased, while concentrations of sodium, calcium, and magnesium increased after diuretics. Although these studies do not elucidate the intrarenal mechanisms controlling zinc excretion, they do suggest that the renal handling of zinc differs markedly from other divalent cations.
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