Abstract
The dissociation of axon filaments, the major fibrous protein of nerve axoplasm, has been studied by two independent methods, ultracentrifugation and viscosimetry, and light scattering. Both methods agree in demonstrating a marked decrease in molecular weight of filaments when the pH is raised from 6.0 to 7.7. During this process the length of the filaments decreases only slightly, while the diameter decreases markedly. It is not possible at present to distinguish a lateral splitting of filaments into nearly equal parts from a splitting off of much smaller material from the filaments. This dissociation of filaments is reversible and occurs in the region of physiological pH of axoplasm which was found to be 6.4. Axon filaments are shown by electrophoresis to be very highly charged compared to other macromolecullar components of axoplasm.
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