Abstract
ALTERATIONS in the permeability of the surface membrane might play a key role in the control of DNA synthesis and cell division1–3. Evidence that changes in hexose transport might participate in growth control comes from reports that uptake of certain hexoses (1) increases after transformation by tumour viruses4–6, and correlates with the expression of the transformed phenotype7; (2) decreases when untransformed fibroblasts reach a density-inhibited monolayer5,8, and (3) rapidly increases after initiating cell division with serum or other agents8,9. We now report, however, that increased hexose transport and initiation of proliferation can be uncoupled in density-inhibited 3T3 mouse fibroblasts. Levels of cortisol which initiate DNA synthesis and division of these cells10,11 actually decrease hexose transport. In addition, some serum components increase hexose transport without initiating proliferation.
Published Version
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
