Abstract
In the present study, we evaluated the relationship between hypertension and the antinociceptive effect of clonidine in genetically hypertensive rats. Intraperitoneal (i.p.) administration of clonidine (0.69 mg/kg) produced hypoalgesia without lowering blood pressure in conscious spontaneously hypertensive (SH), spontaneously hypertensive-stroke prone (SH-SP) and Wistar-Kyoto (WKY) rats. The antinociceptive effect of clonidine, measured by the hot plate method, was greater in the hypertensive rats (SH and SH-SP) than in their normotensive controls (WKY). The enhancement of clonidine-induced antinociception in these genetically hypertensive rats was not altered after acute lowering of blood pressure with guanethidine. Furthermore, the development of this hyper-antinociceptive effect of clonidine was earlier than that of hypertension in SH rats. In conclusion, our data suggest that the enhanced antinociceptive effect of clonidine in hypertensive animals is not directly related to blood pressure.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
