Abstract
The present communication describes the dissociation of ribosomes of mammalian origin, induced by high concentrations of heparin. Heparin, like polyvinyl sulfate is a well known inhibitor of RNAse ( Flanagan, 1967). It was systematically used by us in experiments designed to study the variation in the ratio: polysomes — free ribosomes in HeLa cells partially synchronized by thymidine. Recent results with dextran sulfate (Miyazawa & al.), another sulfonated polyanion which depolymerizes ribosomes, prompted us to investigate the effects of heparin.
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