Abstract
The rate of transport of alpha-aminoisobutyric acid (AIB) has been measured in Swiss 3T3 cells at different cell densities in the range 10(3) to 5 x 10(4) cells/cm2. There is a pronounced increase in the rate of Na+-dependent AIB uptake below 4 x 10(3) cells/cm2, which can be observed both in growing cells (10% serum) or in cells arrested early in the G1 (G0) portion of the cell cycle in medium containing plasma-derived serum. The rate of AIB transport of cells arrested in G0 can be inhibited by the addition of a plasma membrane-enriched fraction prepared from 3T3 cells. The results are interpreted in terms of two elements that control the rate of AIB transport, one dependent on the position in the cell cycle and the other on cell contact. Preliminary observations suggest that BALB 3T3 cells behave in a similar way.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
