Dissociating the neural substrates for inhibition and shifting in domain-general cognitive control.

Abstract

Inhibition and shifting are two key components of domain-general cognitive control. Numerous studies have investigated the neural substrates of both components, but it is still unclear whether the relevant brain regions are specifically involved in one specific component or commonly engaged in both components. Here, we addressed this question by using functional magnetic resonance imaging and a modified saccade paradigm that was effective to disentangle inhibition and shifting in one experiment. The results showed that both the middle frontal gyrus and left parietal lobe were involved in both components but the middle frontal gyrus was more active for the inhibition while the inferior parietal lobe was more active for the shifting processing. The outcome suggests that, although both regions are engaged in inhibition and shifting, each plays a dominant role in one component. These findings provide a further insight into the neural dissociation in inhibition and shifting, as well as a better explanation on the framework of unity and diversity from a neuropsychological viewpoint.