Disseminated Mycobacterium haemophilum Infection in a Renal Transplant Recipient Complicated by Immune Reconstitution and Hypercalcemia

Abstract

A 48-year-old renal transplant recipient developed fevers, arthralgia, and peripheral skin nodules approximately 1 year after transplantation. Culture of a skin nodule grew Mycobacterium haemophilum. Antimycobacterial therapy was instituted, and his immunosuppressant regimen was reduced. His course was complicated by development of an immune reconstitution inflammatory syndrome and profound hypercalcemia. He completed 18 months of antimycobacterial therapy during which time the signs and symptoms of infection resolved, and he remains without evidence of residual infection six months after completion of therapy.