Disseminated juvenile xanthogranulomas with underlying neurotrophic tyrosine receptor kinase fusion and response to larotrectinib.

Abstract

Recent molecular characterizations of histiocytoses, including juvenile xanthogranuloma (JXG), have identified diverse kinase gene mutations, suggesting that various targeted therapies may be promising treatments for these lesions. We herein present a case of an infant with disseminated JXG lesions with an underlying NTRK mutation who was successfully treated with larotrectinib.