Abstract
Disseminated intravascular coagulation (DIC) is a dynamic pathologic process in which thrombin is formed in the vascular system. 1 Spero JA Lewis JH Hasibi U Disseminated intravascular coagulation: Findings in 346 patients. Thromb Haemost. 1980; 43: 28 PubMed Google Scholar It is characterized by the widespread pathologic activation of the coagulation cascade, leading to thrombosis in a variety of sites and resulting in ischemia, necrosis, and abnormalities of function of the organs concerned. The coagulation depletes clotting factors, fibrinogen, and platelets, causing bleeding to occur. This is followed by the secondary activation of the plasmin system, which breaks down fibrin into its degradation products. 2 Samman N Disseminated intravascular coagulation and facial injury. Br J Oral Maxillofac Surg. 1984; 22: 295 Abstract Full Text PDF PubMed Scopus (7) Google Scholar The fibrin degradation products (FDPs) have an inhibitory effect on platelet aggregation and adhesion, leading to aggravation of the bleeding tendency. Although there are a long list of diseases complicated by DIC, it is most frequently associated with obstetric catastrophes, metastatic malignancy, massive trauma, and bacterial sepsis. 3 Handin RI Coagulation disorders. in: ed 11. Harrison's Principles of Internal Medicine. McGraw-Hill, New York, NY1988: 475-1480 Google Scholar
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