Disseminated cryptococcosis causing liver dysfunction in a pug

Abstract

AbstractA nearly 2‐year‐old, male, neutered pug was referred for a 1‐month duration of progressive gastrointestinal signs and lethargy, and possible seizure activity. Blood analyses before referral had shown marked increases in hepatocellular and hepatobiliary enzymes and increased pre‐prandial and post‐prandial bile acids, with normal bilirubin. Physical exam revealed a quiet mentation and blood analyses at the time of presentation found persistent increases in hepatic enzymes, and hypoalbuminaemia. Abdominal ultrasound identified intra‐abdominal free fluid and ileocolic lymphadenopathy. Cytology of the abdominal effusion, liver and abdominal lymph nodes identified organisms of the Cryptococcus genus. The dog had a positive Cryptococcus antigen lateral flow assay titre of 1:>10,000, confirming cryptococcosis. The dog was euthanased following diagnosis. This is the first report describing a case of disseminated cryptococcosis causing liver dysfunction in a veterinary species. Cryptococcus infection should be considered in a young dog presenting with gastrointestinal signs and liver enzymopathy.