Abstract
THE ADMINISTRATION of chemotherapy to patients with adult acute nonlymphocytic leukemia presently yields a 50% to 60% complete remission rate.<sup>1</sup>Death from infection remains a major factor in preventing a higher proportion of patients from obtaining a complete remission.<sup>2</sup>Candidiasis is the most frequent fungal infection in patients with leukemia<sup>3</sup>and is often difficult to treat despite the use of amphotericin B with or without flucytosine. Amphotericin B may cause true anaphylaxis, fever, chills, hypotension, skin rash, nausea, vomiting, anorexia, anemia, azotemia, and renal tubular acidosis.<sup>4,5</sup> Miconazole nitrate is a synthetic 1-phenethylimidazole derivative, 1-2,4-dichloro-β(2,4-dichlorobenzyloxy) phenethylimidazole nitrate with broad-spectrum antifungal and antibacterial activity.<sup>6</sup>Miconazole has been used in the treatment of coccidioidomycosis with moderate success.<sup>7</sup>Phlebitis at the site of infusion has been the only recognized side effect and can often be avoided by the use of a central venous catheter. We report here the
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