Disseminated Aspergillosis due toAspergillus nigerin Immunocompetent Patient: A Case Report

Ulku Ergene,Sebnem Senol,Zeynep Akcali,Demircan Ozbalci,Nalan Nese

doi:10.1155/2013/385190

Abstract

Invasive aspergillosis is a major cause of morbidity and mortality in immunocompromised patients. Many cases of pulmonary, cutaneous, cerebral, and paranasal sinus aspergillosis in immunocompetent patient were defined in literature but disseminated aspergillosis is very rare. Here we present an immunocompetent case with extrapulmonary disseminated aspergillosis due to Aspergillus niger, totally recovered after effective antifungal treatment with voriconazole.

Highlights

Hundreds of Aspergillus conidia survive within the inhaled air, no disease development occurs at immune competent individuals [1]
Extra-pulmonary aspergillosis occurs in 25–60% of cases and may involve the central nervous system, liver, skin, and gastrointestinal system [4,5,6]
We would like to present an immunocompetent case with extra-pulmonary disseminated aspergillosis totally recovered after effective antifungal treatment with voriconazole

Summary

Introduction

Hundreds of Aspergillus conidia survive within the inhaled air, no disease development occurs at immune competent individuals [1]. Immunosuppression increases the risk of dissemination of the Aspergillus to all of the solid organs via circulation or by direct tissue invasion [2]. Extra-pulmonary aspergillosis occurs in 25–60% of cases and may involve the central nervous system, liver, skin, and gastrointestinal system [4,5,6]. In the immunocompetent cases, disseminated aspergillosis is infrequently reported [7].

Results

Conclusion