Abstract
When carbon-starved, the budding yeast Saccharomyces cerevisiae gels its cytoplasm. This reversible transition from a liquid-like to a solid-like state maintains the viscoelastic properties of the cytoplasm, but with many proteins assembled into higher order structures. This process is protective for the cell–if inhibited, the cell cannot recover from starvation. Our newly developed method for in-cell NMR allows us to study proteins in their native cellular environment. We aim to use in-cell NMR in budding yeast to explore changes in the cellular environment and to determine the molecular mechanisms that make gelation protective.
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