Abstract
Dissecting the Immune Component of Neurologic Disorders: A Grand Challenge for the 21st Century
Highlights
The immune system is a complex mobile and reactive entity that performs surveillance on, and comes in contact with, every organ of the body
It is important to recognize, since it is a corticosteroid-responsive encephalopathy. Another example involves a spectrum of disorders resulting from immune reactivity to synapse components. They produce a wide variety of neuropsychiatric disturbances, characterized by catatonia, memory deficits, movement disorders, psychosis, and seizures (Rosenfeld and Dalmau, 2011)
Paraneoplastic disorders are yet another expanding neuroimmune area (Greenlee, 2010). They are defined as remote effects of malignancies, and can target virtually any site within the neuraxis (CNS, peripheral nervous system (PNS), or neuromuscular junction)
Summary
The immune system is a complex mobile and reactive entity that performs surveillance on, and comes in contact with, every organ of the body. The list of neurologic diseases in which the immune system plays an important role continues to grow. Another example involves a spectrum of disorders resulting from immune reactivity to synapse components. There is a host immune response against one or more intracellular or cell membrane neuronal or glial antigens, often marked by suggestive antibodies.
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