Abstract
To determine the association of opening the paravesical space in relation to its occurrence of de novo SUI in an animal model. Thirty five female Sprague Dawley rats were divided into 5 groups of 7 rats each: Control group, Sham groups(F, H), and Study groups(MF, MH). Groups labeled with “F” had the paravesical space opened, “H” had tissue dissection with no opening of the space, and “M” had mesh implanted inside the vaginal wall. Urodynamic studies, immunohistochemical analysis, and western blot were done at day 40. The mean weight and age of 35 rats were 302.1 ± 25.1 grams and 12.8 ± 1.2 weeks old. No significant differences were noted among the control, Sham F, Sham H, Study MF, and Study MH on the voiding pressure and voided volume. The Sham F and Study MF (opened paravesical space) groups had significantly lower values on leak point pressures (LPP) (p = 0.026; p < 0.001) and shorter voiding intervals (p = 0.032; p = 0.005) when compared to other groups. Immunohistochemical analysis showed IL-1 and TNF-α to be intensely increased for the Study MF group (p = 0.003; p = <0.001). MMP-2 and CD 31 markers were also significantly higher in the Study MH and MF group. NGF expression was significantly increased in the Study MF and Sham F groups. Thus, opening of the paravesical space causes an increased inflammatory reaction, which leads to tissue destruction and lower urinary tract dysfunction, exemplified in the study with low leak point pressure and shortened voiding intervals.
Highlights
To determine the association of opening the paravesical space in relation to its occurrence of de novo Stress urinary incontinence (SUI) in an animal model
Immunohistochemical analysis showed IL-1 and TNF-α to be intensely increased for the Study MF group (p = 0.003; p =
The similarity that these two separate studies shares is that, these mesh kits utilizes the anterior approach for bilateral sacrospinous ligament fixation. This procedure entails opening the paravesical space, in which Lo et al.[3,4] in his two studies has postulated that opening this space could lead lowering of the mean urethral closure pressure (MUCP), SUI
Summary
To determine the association of opening the paravesical space in relation to its occurrence of de novo SUI in an animal model. The similarity that these two separate studies shares is that, these mesh kits utilizes the anterior approach for bilateral sacrospinous ligament fixation This procedure entails opening the paravesical space, in which Lo et al.[3,4] in his two studies has postulated that opening this space could lead lowering of the mean urethral closure pressure (MUCP), SUI. Results of the study showed increased sub-urethral tissue matrix metalloproteinase and nerve growth factor expression that relates to tissue remodeling after prolene mesh implantation for stress urinary incontinence. Based on these studies, replicating SUI was possible in mice which made the authors come up with the idea to replicate corrective prolapse surgeries that open the paravesical space to be able determine its’ association in relation to the occurrence of de novo SUI
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
