Abstract
Iron homeostasis is a dynamic process that is tightly controlled to balance iron uptake, storage, and export. Reduction of dietary iron from the ferric to the ferrous form is required for uptake by solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2 (Slc11a2) into the enterocytes. Both processes are proton dependent and have led to the suggestion of the importance of acidic gastric pH for the absorption of dietary iron. Potassium voltage-gated channel subfamily E, member 2 (KCNE2), in combination with potassium voltage-gated channel, KQT-like subfamily, member 1 (KCNQ1), form a gastric potassium channel essential for gastric acidification. Deficiency of either Kcne2 or Kcnq1 results in achlorhydia, gastric hyperplasia, and neoplasia, but the impact on iron absorption has not, to our knowledge, been investigated. Here we report that Kcne2-deficient mice, in addition to the previously reported phenotypes, also present with iron-deficient anemia. Interestingly, impaired function of KCNQ1 results in iron-deficient anemia in Jervell and Lange-Nielsen syndrome patients. We speculate that impaired function of KCNE2 could result in the same clinical phenotype.
Highlights
Iron homeostasis is a dynamic process that is tightly controlled to balance iron uptake, storage, and export
Ferric form and requires reduction to the ferrous form before being transported by solute carrier family 11, member 2 (Slc11a2), which is located in the brush border of the enterocytes [1]
Gastric pH has been suggested to be a critical determinant for dietary iron absorption, a theory supported by the observation that the sublytic mouse model, with a point mutation in Atp4a (Kþ/Hþ-ATPase a-subunit), has increased gastric pH and iron-deficient anemia [9]
Summary
Iron homeostasis is a dynamic process that is tightly controlled to balance iron uptake, storage, and export. Histopathology Full necropsy was performed on two male and two female Kcne2tm1a/tm1a mice and two controls of each sex. Results and discussion Seven hematologic parameters were significantly different in male Kcne2tm1a/tm1a mutants compared with controls (Table 1; Supplementary Table E1, online only, available at www.exphem.org).
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