Abstract

This work establishes the synergistic efficacy of combined FLT3 and LSD1 inhibition in FLT3-ITD AML by disrupting STAT5 and GFI1 binding at the MYC blood-specific superenhancer complex.

Full Text
Published version (Free)

Talk to us

Join us for a 30 min session where you can share your feedback and ask us any queries you have

Schedule a call

Similar Papers

Paper Title
Journal
Date
Author
Data from Disruption of the MYC Superenhancer Complex by Dual Targeting of FLT3 and LSD1 in Acute Myeloid Leukemia
Shannon K Mcweeney ... Daniel Bottomly
-
Shannon K Mcweeney, et. al.Shannon K Mcweeney ... Daniel Bottomly
19 Apr 2023
Data from Disruption of the MYC Superenhancer Complex by Dual Targeting of FLT3 and LSD1 in Acute Myeloid Leukemia
Garth Kong ... Jake Vancampen
-
Garth Kong, et. al.Garth Kong ... Jake Vancampen
19 Apr 2023
FLT3 and LSD1 Inhibitor Combinations Synergistically Repress Growth of FLT3-Mutant Acute Myeloid Leukemia Via Blockage of MYC Function
Jake Vancampen ... Cody Coblentz
Blood | VOL. 136
Jake Vancampen, et. al.Jake Vancampen ... Cody Coblentz
05 Nov 2020
Abstract 3269: Dual targeting of FLT3 and LSD1 disrupts the MYC super-enhancer complex in acute myeloid leukemia
William M Yashar ... Daniel J Coleman
Cancer Research | VOL. 82
William M Yashar, et. al.William M Yashar ... Daniel J Coleman
15 Jun 2022
View more papers

More From: Molecular cancer research : MCR

Paper Title
Journal
Date
Author
Hepatitis B virus X protein represses expression of tumor suppressor PTPN18 in hepatocellular carcinoma.
Zhenyu Zhou ... Jianlong Zhang
Molecular cancer research : MCR | VOL. -
Zhenyu Zhou, et. al.Zhenyu Zhou ... Jianlong Zhang
24 May 2024
Crizotinib enhances PARP inhibitor efficacy in ovarian cancer cells and xenograft models by inducing autophagy.
Janice M Santiago-O'Farrill ... Zhen Lu
Molecular cancer research : MCR | VOL. -
Janice M Santiago-O'Farrill, et. al.Janice M Santiago-O'Farrill ... Zhen Lu
23 May 2024
USP44 overexpression drives a MYC-like gene expression program in neuroblastoma through epigenetic reprogramming.
Thomas L Ekstrom ... Paul J Galardy
Molecular cancer research : MCR | VOL. -
Thomas L Ekstrom, et. al.Thomas L Ekstrom ... Paul J Galardy
22 May 2024
miR-497 target gene regulatory network in angiosarcoma.
Annaleigh Benton ... Jason A Hanna
Molecular cancer research : MCR | VOL. -
Annaleigh Benton, et. al.Annaleigh Benton ... Jason A Hanna
21 May 2024
View more papers