Abstract
The disruption of guanylyl cyclase/natriuretic peptide receptor A (GC-A/NPRA) gene (Npr1) leads to elevated arterial blood pressure, cardiac hypertrophy, congestive heart failure, and sudden death in mice lacking NPRA. ANP-NPRA signaling is known to counteract the renin-angiotensin-aldosterone system (RAAS). We studied whether Npr1 gene copy number affects adrenal angiotensin II (Ang II) and aldosterone (ALDO) levels in a gene-dose dependent manner in Npr1 gene-targeted mice. Adrenal Ang II and ALDO levels increased in one-copy (gene-disrupted heterozygous allele, 15%, p
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
