Abstract
Inadequate sleep prevails in modern society and it impairs the circadian transcriptome. However, to what extent acute sleep deprivation (SD) has impact on the circadian rhythms of peripheral tissues is not clear. Here, we show that in mouse lung, a 10-h acute sleep deprivation can alter the circadian expression of approximately 3,000 genes. We found that circadian rhythm disappears in genes related to metabolism and signaling pathways regulating protein phosphorylation after acute sleep deprivation, while the core circadian regulators do not change much in rhythmicity. Importantly, the strong positive correlation between mean expression and amplitude (E-A correlation) of cycling genes has been validated in both control and sleep deprivation conditions, supporting the energetic cost optimization model of circadian gene expression. Thus, we reveal that acute sleep deprivation leads to a profound change in the circadian gene transcription that influences the biological functions in lung.
Highlights
Lack of sleep is a commonplace in modern society
The animals in the control group were housed under 12 h: 12 h light/dark cycle, while the animals in the acute sleep deprivation group (SD) were kept awake for 10 h from 6 AM. to 4 PM according to a sleep deprivation paradigm
The comparison between control and SD conditions was restricted to genes that were sufficiently expressed in both datasets, with a cutoff of FPKM > 1 in at least 80% samples (16,505 genes left in the final dataset)
Summary
Lack of sleep is a commonplace in modern society. Inadequate sleep leads to decreased performance and deterioration in health. Inadequate or irregular sleep can disrupt the circadian rhythms in the brain, and in peripheral tissues (Huang et al, 2011; Moller-Levet et al, 2013; Archer and Oster, 2015). It has bad consequences on the outcome of health and is associated with several medical conditions, including diabetes, heart disease, stroke, high blood pressure, kidney disease, and mood disorders (Goel et al, 2013; Touitou et al, 2017). In the pulmonary system, disruption of circadian rhythm accelerates lung cancer due to the enhanced cell proliferation and the metabolic deregulation (Papagiannakopoulos et al, 2016)
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