Abstract
Alzheimer’s disease is accompanied by a number of pathological modifications, from those at the subcellular level to the impairment of cognitive cerebral functions. Abnormal accumulation of a specific protein, β-amyloid, in brain neurons plays a central role in the pathogenesis of this neurodegenerative disease. In this case, one significant pathogenetic factor is disruption of calcium homeostasis in cerebral cells. In this review, we describe changes in the intracellular calcium signalling related to Alzheimer disease, namely disorders of the functioning of main intracellular calcium stores (mitochondria and endoplasmic reticulum), as well as of those of calcium channels of the plasma membrane.
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