Disrupted-in-schizophrenia 1 in the intracellular calcium homeostasis

Abstract

Event Abstract Back to Event Disrupted-in-schizophrenia 1 in the intracellular calcium homeostasis Sung-Jin Park1 and Sang Ki Park1* 1 Pohang University of Science and Technology, Department of Life Sciences, Korea, South DISC1 (Disrupted-in-schizophrenia 1) has emerged as a convincing susceptibility factor for the major mental illnesses including schizophrenia, recurrent major depression, and bipolar disorders, but its mechanistic links to the diseases are yet to be fully understood. The calcium plays essential roles in diverse and fundamental biological processes of a cell and an organism. This maximized functional variety of calcium is based on its fast effects and its spatially and temporally dynamic properties, which is heavily dependent on the calcium buffering function of organelles such as endoplasmic reticulum (ER) and mitochondria. We found that DISC1 deficiency caused abnormalities in calcium buffering function of ER and mitochondria. DISC1 deficiency caused an exaggerated oscillation pattern of mitochondrial calcium concentration. Also, DISC1 is recruited to inositol-1,4,5-trisphosphate receptor 1 (IP3R1). The abnormality in the transport of calcium between ER and mitochondria was also observed, which implies that functionalities of the mitochondria-associated ER membrane were also affected. These results collectively indicate that DISC1 is a key regulatory factor of intracellular calcium dynamics. Works on its mechanistic aspects are in progress and we believe that the results will provide novel insight into the molecular events associated with major mental disorders. Keywords: Schizophrenia, bipolar disorders, mental illness, calcium homeostasis, DISC-1 Conference: 14th Meeting of the Asian-Pacific Society for Neurochemistry, Kuala Lumpur, Malaysia, 27 Aug - 30 Aug, 2016. Presentation Type: Symposium 2: Common Molecular Aspects of Neurodevelopmental and Psychiatric Disorders Topic: 14th Meeting of the Asian-Pacific Society for Neurochemistry Citation: Park S and Park S (2016). Disrupted-in-schizophrenia 1 in the intracellular calcium homeostasis. Conference Abstract: 14th Meeting of the Asian-Pacific Society for Neurochemistry. doi: 10.3389/conf.fncel.2016.36.00011 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 26 Jul 2016; Published Online: 11 Aug 2016. * Correspondence: Prof. Sang Ki Park, Pohang University of Science and Technology, Department of Life Sciences, Pohang, Kyungbuk, Korea, South, skpark@postech.ac.kr Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Sung-Jin Park Sang Ki Park Google Sung-Jin Park Sang Ki Park Google Scholar Sung-Jin Park Sang Ki Park PubMed Sung-Jin Park Sang Ki Park Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.