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Abstract
Using radiotracer techniques, the disposition of vitamin A in the albino eye was studied following instillation of its solution in arachis oil in tear chamber, Early peak times were observed in the conjunctiva and the cornea suggesting rapid uptake of the drug by these tissues. Perhaps because of their proximity to the fear pool, these two tissues possessed the highest concentration of vitamin A. Sustained drug concentration was evident in all the ocuiar tissues studied—conjunctiva, cornea, aqueous humor and iris-ciliary body—beginning at 30 min post-instillation. This presumably was due to a reservoir for vitamin A in the precorneal area and perhaps the corneal epithelium; the nature of this reservoir has yet to be resolved. The significance was that vitamin A was available to the conjunctiva and the cornea from topical dosing, the two tissues known to undergo changes in vitamin A deficiency and dry-eye states. Unfortunately, these data as yet do not permit the formulation of a dosage regimen for topically applied vitamin A in the treatment of xerophthalmia.
Published Version
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