Abstract
The distribution, excretion and metabolism of recombinant human interleukin-2 (S-6820) were studied using 125I-labeled compound (125I-S-6820)1. At 5min after intravenous injection of 125I-S-6820 to male and female rats, high radioactivity was observed in the kidney. Radioactivities in the other organs were lower than the serum level. Results obtained by whole-body autoradiography showed that high concentrations of radioactivity were found in the cortex renis.2. At 5min after intravenous injection of 125I-S-6820 to 20-th day pregnant rats, no radioactivities were detected in the amniotic fluid and fetus.3. Within 24hr after intravenous injection of 125I-S-6820, 78% and 1 % of administered radioactivity were excreted in the urine and feces, respectively. However, 98% of excreted radioactivity in the urine was not precipitated with trichloroacetic acid.4. In the kidney after intravenous injection of 125I-S-6820, a low molecular weight degradation products of 125I-S-6820 were observed as revealed by gel filtration radio-chromatography. In addition, micro-autoradiogram of cortex renis after intravenous injection of 125I-S-6820 showed that S-6820 was likely to be ultrafiltrated by the glomerulus and absorbed by proximal tubules. S-6820 appeared to be degraded in the kidney.
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