Abstract
The bioavailability and pharmacokinetics in turkeys of cefquinome (CFQ), a broad-spectrum 4th-generation cephalosporin antibiotic, were explored after a single injection of 2 mg/kg body weight by intravenous (IV) and intramuscular (IM) routes. In a crossover design and 3-weeks washout interval, seven turkeys were assigned for this objective. Blood samples were collected prior to and at various time intervals following each administration. The concentration of CFQ in plasma was measured using HPLC with a UV detector set at 266 nm. For pharmacokinetic analysis, non-compartmental methods have been applied. Following IV administration, the elimination half-life (t1/2ʎz), distribution volume at steady state (Vdss), and total body clearance (Cltot) of CFQ were 1.55 h, 0.54 L/kg, and 0.32 L/h/kg, respectively. Following the IM administration, CFQ was speedily absorbed with an absorption half-life (t1/2ab) of 0.25 h, a maximum plasma concentration (Cmax) of 2.71 μg/mL, attained (Tmax) at 0.56 h. The bioavailability (F) and in vitro plasma protein binding of CFQ were 95.56% and 11.5%, respectively. Results indicated that CFQ was speedily absorbed with a considerable bioavailability after IM administration. In conclusion, CFQ has a favorable disposition in turkeys that can guide to estimate optimum dosage regimes and eventually lead to its usage to eradicate turkey’s susceptible bacterial infections.
Highlights
All obtained values are expressed as Mean ± standard deviation (SD). No abnormalities such as irritation, pain signs, or lameness were noticed in turkeys. No abnormalities such as irritation, pain signs, or lameness were noticed in turkeys following the administrations of CFQ
The semi-logarithmic plasma concentration vs. time time curves of CFQ after the single IV and IM administration of 2 mg/kg body weight (BW) are illustrated curves of CFQ after the single IV and IM administration of 2 mg/kg BW are illustrated in in Figure 3 and the mean ± SD of pharmacokinetic parameter values are shown in Table
Semi-logarithmicgraph graph depicting time-concentration of cefquinome in plasma of Figure depicting thethe time-concentration of cefquinome in plasma of turturkeys a single intravenous
Summary
Publisher’s Note: MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations. Pathogenic bacteria constitute a menace to the health of humans and animals and lead to a significant economic burden; an antibacterial intervention is a vital consideration [1]. The emergence of bacterial resistance to antibacterials is a constant medical issue due to the regular and hazardous use of classical antibiotics. This problem can partly be solved by the usage of appropriate and effective antibacterial drugs
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
