Dispose to the pole—protein aggregation control in bacteria

Abstract

The disaggregation and refolding of polypeptides aggregated in bacterial cells in response to environmental stress is crucial for the development of thermotolerance. Although the mechanistic aspects of the chaperone‐dependent disaggregation reaction are known, the spatio‐temporal organization of this process is less understood. In this issue, Winkler et al (2010) present the results of technically advanced studies on the organization of this process and its biological consequences in bacterial cells.