Disposable electrochemical sensor based on modified screen printed electrode for sensitive cabergoline quantification

Abstract

In the present study, a screen printed electrode (SPE) modified with La2O3/Co3O4 nanocomposite (La2O3/Co3O4/SPE) has been developed and employed for sensitive and selective quantification of an ergot derivative drug cabergoline with exceptional accuracy and precision in phosphate buffer solution (PBS) at pH7.0 using different pulse voltammetry (DPV) technique. Electrochemical properties of constructed La2O3/Co3O4/SPE sensor were explored by various characterization techniques. Excellent La2O3/Co3O4/SPE electrochemical properties offer sensitive cabergoline voltammetric determination with low detection limit, good stability and quick response towards electro catalytic oxidation of cabergoline as compared to bare SPE. A single irreversible oxidation peak was observed at a potential of 550mV and 800mV on the La2O3/Co3O4/SPE and bare SPE, respectively. Under optimized conditions, DPV current demonstrates a linear response for cabergoline over a concentration range of 0.1 to 100.0μM with a correlation coefficient (R) of 0.9987, a detection limit (LOD) (S/N=3) 0.04μM. The proposed disposable sensor revealed a high sensitivity and was effectively exploited for the cabergoline determination in real samples.