Abstract
We have developed stable chitosan colloids over a wide pH range without cross-linkers or gelling agents. The colloid was prepared using chitosan nanoparticle obtained from pulverization of bulk chitosan powder, followed by surface treatment using small amount of ascorbic acid (AA) and polyglycerol monostearate (PGMS) in water. Chitosan nanoparticles were well dispersed in a diluted AA solution due to the protonation of the chitosan chain on the surface. And then, the addition of PGMS led them to exhibit highly stable dispersion even in alkali conditions and 50 °C. The hydrodynamic diameter of the colloid was monitored using dynamic light scattering and the real image of the colloid was obtained using cryo-electron microscope measurement. This chitosan colloid will be useful for developing food ingredients or drug carrier templates that should be stable over a wide pH range.
Highlights
Chitosan obtained from deacetylation of chitin is a biodegradable cationic polymer and known as a useful biomaterial for food ingredients[1,2,3] and protein delivery,[4,5,6] cosmetics,[7] drug[8,9,10] and gene delivery,[11,12,13] tissue engineering,[14] and so on
It broke down into smaller and irregular shaped particles with few hundred nanometers in an average size with a wide distribution (Figure 1(b) and inset). This nanoparticle was mixed at various concentrations with four organic acid solutions that were used to solubilizing chitosan.[38]
We studied the chitosan colloid stability by increasing pH, where the colloid prepared at 0.2 wt% ascorbic acid (AA) was used
Summary
Chitosan obtained from deacetylation of chitin is a biodegradable cationic polymer and known as a useful biomaterial for food ingredients[1,2,3] and protein delivery,[4,5,6] cosmetics,[7] drug[8,9,10] and gene delivery,[11,12,13] tissue engineering,[14] and so on. In spite of these potential applications, the use of chitosan has been limited because it is soluble only in acidic conditions, where the amine group is protonated to lead electrostatic repulsion between the chitosan chains. Submicron size was suitable for parenteral applications as well as noninvasive mucosal applications, such
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