Abstract
Background and ObjectivesAlthough there was growing evidence supporting the hypothesis that Notch1 was one of the few candidate genes linked with colorectal cancer (CRC) susceptibility, the precise level of Notch1 protein expression in benign and malignant colorectal diseases was still unknown. Our study has investigated the Notch1 expression in benign and malignant colorectal diseases as well as to investigate the role and clinicopathological significance of aberrant expression of Notch1 in CRC.MethodsThe protein expression of Notch1 was examined by immunohistochemistry in 901 clinical specimens with colorectal diseases, including 220 patients with ulcerative colitis, 232 patients with colorectal adenoma and 449 patients with colorectal cancer. Associations between the expression of Notch1 and various clinicopathological features, as well as survival status, were studied.ResultsCytoplasmic Notch1 was expressed in 7.7% of patients with ulcerative colitis, 14.7% of patients with colorectal adenoma and 58.0% of patients with colorectal cancer, respectively. Colorectal cancer patients with high expression levels of Notch1 showed lower overall survival (OS) and disease-free survival (DFS) rates than those patients with low Notch1 expression.ConclusionsExpression level of Notch1 was gradually increased from precancerous lesions to cancer. It might play as an oncogene in the CRC development, and might be potentially used as a biomarker for prognosis of CRCs.
Highlights
Colorectal cancer (CRC) is among the most frequent types of malignancy
The immunohistochemical analysis was performed from 220 ulcerative colitis patients, 232 colorectal adenoma patients, and 449 colorectal cancer patients
In the colorectal cancer group 12 of 449 patients have a history of the benign colon lesions, 9 patients with ulcerative colitis, 3 patients with colorectal adenoma
Summary
Colorectal cancer (CRC) is among the most frequent types of malignancy. Early diagnosis and prediction of prognosis of colorectal cancer has become important. Ulcerative colitis and colorectal adenoma are benign bowel diseases, but there is the possibility of canceration [2,3,4]. Studying the relationship between precancerous lesions and tumors plays an important role in the prevention of colorectal cancer. There was growing evidence supporting the hypothesis that Notch was one of the few candidate genes linked with colorectal cancer (CRC) susceptibility, the precise level of Notch protein expression in benign and malignant colorectal diseases was still unknown.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
