Abstract
Summary Component: role limitations-emotional, social functioning, and mental health] and the Health Status item from the EUROQoL-5D. Psychopathology was assessed with the five symptom dimensions from PANSS: positive, negative, cognitive, depression, and excitement symptoms. Results Significant intercorrelations were found among QLS subscales: IRP with IRF [r(38) = 0.65, p < 0.001], IF [r(38) = 0.85, p < 0.001], and COA [r(38) = 0.70, p <0.001]; IRF with IF [r(38) = 0.74, p < 0.001] and COA [r(40) = 0.62, p < 0.001]; IF with COA [r(38) = 0.74, p < 0.001]. Also, significant intercorrelations were found between subjective quality of life ratings: Physical Component-SF-36 with Mental Component-F-36 [r(38) = 0.76, p < 0.001] and Health Status [r(38) = 0.70, p = 0.001]; Mental Component-36 with Health Status [r(38) = 0.67, p = 0.001]. However, the four QLS subscales did not correlate with patient-reported quality of life ratings, except IRP with Mental Component-F-36 [r(38) = 0.42, p = 0.01]. Negative symptoms were significantly related with scores on the IPR [r(38) = -0.77, p = 0.001], IRF [r(38) = -0.46, p = 0.01], IF [r(38) = -0.70, p = 0.001], and COA [r(38) = 0.63, p = 0.001], whereas cognitive symptoms with scores on the IPR [r(38) = -0.37, p = 0.05] and IF [r(38) = -0.33, p = 0.05]. Mental Component was significantly correlated with positive symptoms [r(38) = -0.37, p = 0.05] and negative symptoms [r(38) = -0.39, p = 0.05], while Health Status was significantly associated with depression [r(38) = -0.32, p = 0.05]. No other significant relationships were found between quality of life scales and symptom ratings.
Highlights
Poor objective and subjective quality of life has been repeatedly reported in schizophrenia
Significant intercorrelations were found among Quality of Life Scale (QLS) subscales: IRP with Instrumental Role Functioning (IRF) [r(38) = 0.65, p < 0.001], Intrapsychic Foundations (IF) [r(38) = 0.85, p < 0.001], and Common Objects and Activities (COA) [r(38) = 0.70, p
Significant intercorrelations were found between subjective quality of life ratings: Physical Component-SF-36 with Mental Component-F-36 [r(38) = 0.76, p < 0.001] and Health Status [r(38) = 0.70, p = 0.001]; Mental Component-36 with Health Status [r(38) = 0.67, p = 0.001]
Summary
Poor objective (observer-rated) and subjective (patientrated) quality of life has been repeatedly reported in schizophrenia. A disparity between objective and subjective ratings of quality of life in schizophrenia has been found in cross-sectional as well as longitudinal studies. Different clinical measures are determinants of observer-rated and patient-reported quality of life. Objective ratings of quality of life seem to be influenced by positive, negative and depressive symptoms, while patientrated life satisfaction only by affective state. The purpose of the present study was to investigate the relationships between objective and subjective ratings of quality life, as well as the influence of psychopathology in them
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