Abstract
Disparate Functional Responses to β-adrenergic and Ischaemic Challenge in Male and Female Hypertrophic Cardiomyocytes
Highlights
The physiologic changes of human cardiac ageing include left ventricular hypertrophy (LVH), cardiac fibrosis that can subsequently lead to the development of systolic, diastolic heart failure, and atrial fibrillation
In LVH+ve cohorts: left ventricular papillary muscles (LVPM) contribution to LVM was significantly increased in Fabry disease (FD) and hypertrophic cardiomyopathy (HCM), compared to all other groups (FD 13±3%, HCM 10±3%, amyloid 8±2%, aortic stenosis (AS) 7±3%, hypertension 7±2%, controls 7±1%; p
In LVH-ve cohorts: only FD had significantly increased LVPM (11±3%; p
Summary
The physiologic changes of human cardiac ageing include left ventricular hypertrophy (LVH), cardiac fibrosis that can subsequently lead to the development of systolic, diastolic heart failure, and atrial fibrillation. To date, it remains completely unknown which biochemical factor(s) that modulate ageing-associated changes in cardiovascular physiology. In a normal ageing population, we sought to examine whether circulating FSTL-3 level is a predictor of increased left ventricular mass. Bicuspid aortic valve (BAV) is the most common congenital heart defect, affecting up to 2% of the population. One of the major consequences of BAV is the development of progressive dilatation of the aortic root and
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