Disorders Of Mitochondrial Respiration in Rats with Subtotal Cerebral Ischemia Under Conditions of The Use of Modulators of the L-Arginine-No Pathway and Against the Background of The Administration of Omega-3 Polyunsaturated Fatty Acids

Abstract

The urgency of the problem of cerebrovascular diseases can rightfully be defined as an emergency, requiring the concentration of efforts of specialists. This is due to the fact that cerebrovascular diseases of ischemic origin tend to grow, rejuvenate, are associated with a severe clinical course, high rates of disability and mortality. Omega-3 polyunsaturated fatty acids are involved in the implementation of the basic functions of neurons, such as the transmission of impulses and the functioning of receptors. In this regard, it is of interest to study the morphofunctional features of brain neurons in rats with subtotal cerebral ischemia against the background of the introduction of Omega-3 polyunsaturated fatty acids and L-NAME. There was a significant improvement in the parameters of mitochondrial respiration when using succinate as a substrate in the group of animals treated with Omega-3 PUFAs and even greater activation in the groups of animals SCI + L-NAME + Omega-3 and SCI + L-NAME + L-arginine + Omega-3. When malate/glutamate was used as a substrate in these groups, the same trend in respiration was observed as when succinate was used to activate mitochondrial respiration. However, changes in succinate-dependent respiration were more pronounced.