Disminución de las discinesias en un modelo de Parkinson en ratas Wistar, mediada por el fitofármaco Mucuna pruriens

Abstract

Parkinson's disease (PD) is a neurodegenerative disease for which the most effective symptomatic treatment is levodopa; however, the drug can induce dyskinesia (levodopa-induce dyskinesia; LID). Mucuna pruriens (Mp) has shown to be effective for the treatment of PD by reducing the rate of LID. We tested this reduction in dyskinesia in a model of PD and dyskinesia in Wistar rats treated with Mp. We manipulated 28 male animals, distributed in 4 groups: control, LID, L-MP1 (Mp at 75mg/kg), and L-MP2 (Mp at 150mg/kg). PD was induced with 6-hydroxydopamine, and dyskinesia was induced with injection of levodopa and benserazide. We analysed 4 types of abnormal involuntary movements: axial, forelimb, orolingual, and locomotor. All 4 types of movements decreased significantly in the groups treated with Mp: axial dyskinesia (L-Mp1, x=0.05, vs LID, x=1.60); forelimb (L-Mp1, x=1.28, vs LID, x=2.06); orolingual (L-Mp1, x=0.18, vs LID, x=1.34); locomotor (L-Mp1, x=0.17, vs LID, x=1.17). We may conclude that Mp reduces the frequency of dyskinesia depending on the topography dose administered.