Dislipidemia with obstructive sleep apnea (OSAS) in patients over sixty years old

Abstract

Introduction OSAS (obstructive sleep apnea) is a frequent condition characterized by recurrent epizods of upper airway obstruction during sleep, daytime sleepiness and nokturnal hypoxemia. Increased sympathetic nerve activity and metabolic abnormalities are frequent in OSAS. Most of the symptoms, risc factors and predisposition factors are similar both in OSAS and cardiovasculer disease. Hipoxia lead to endothelial dysfunction and oxidation of LDL cholestrol as a result of oxidatif stress in OSAS. A large number of studies demonstrated that plasma lipid and apolipoprotein levels were similar both in OSAS and control groups however in OSAS disfunction of HDL cholestrol and increased oxidized LDL cholestrol levels were found. AHI index is considered to be responsible for the disorder of HDL and LDL cholestrol levels. Materials and methods 40 patients age of 60 and over referred to the sleep clinic suffering from OSAS symptoms and undergone to the diagnostic polisomnography procedure were included in the study. The patients were divided into four subgroups based on the severit. Results 440 patients age of 60 and over referred to the sleep clinic suffering from OSAS symptoms and undergone to the diagnostic polisomnography procedure were included in the study.The patients were divided into four subgroups based on the severity of OSAS. Conclusion In this study, gender was found not to be significantly related with severe OSAS in addition a significant relation of BMI and OSAS was demonstrated (p > 0,05). Whether the patients with dyslipidemia classified according to degree of OSAS and gender received drugs or not did not create a significant difference (p Acknowledgements 1-A report of National Commission on Sleep Disorders Research. Washington, DC U.S. Government Printing Office,1995. 2-Ancoli-Israel S, Kripke DF, Klauber MR, et al. Sleep-disordered breathing in community-dwelling elderly. Sleep 1991; 14:486–95 Monograph 1998:10: 75–105. 3- Bixler EO, Vgontzas AN, Ten Have T,et al.Effect of age on sleep apnea in men I:Prevalence and severtiy. Am J Respir Cirt Care Med 1998;157–148.