Disintegration Properties of Calcium Phosphate Dibasic Dihydrate Tablets

Abstract

The effect of compressional force on the disintegration time of tablets prepared from calcium phosphate dibasic dihydrate containing various tablet disintegrants was examined. The results show that effects of compressional force on disintegration time are of two types. The first type is that of insoluble disintegrants, e.g., starch and a cation‐exchange resin, where the disintegration time initially shows a dramatic decrease. After this decrease, a further increase in compressional force appears to have no effect on the disintegration time. The second type is that of soluble disintegrants, e.g., calcium sodium alginate, sodium carboxy‐methylcellulose, and sodium starch glycolate, where variation in compressional force has very little effect on the disintegration time. These results are discussed in terms of the differing mechanism whereby these substances act as disintegrants.