Disintegration and dissolution characteristics of compressed tablets consisting of hydroxypropyl cellulose and carboxyvinyl polymer.

Abstract

The disintegration and dissolution characteristics of tablets consisting of hydroxypropyl cellulose (HPC) and carboxyvinyl polymer (CP), were studied, considering the interpolymer complex formation between HPC and CP in the tablet. Brilliant blue FCF (BBL) was used as a model compound of a water-soluble drug. A rapid disintegration was observed when the tablet was prepared with the HPC-CP solid complex. In the case of hte physical mixture of HPC and CP, the tablet maintained its original shape during the disintegration test (0-24h). The slowest dissolution of BBL was ovserved in water when the tablet was prepared with the sphysical imxture, and approximately 30% of BBL remained in the solid form in the tablet at 24 h. Althrough the dissolution of BBL from the tablet prepared with the physical mixture was affected by the pH value of the dissolution medium, other factors, such as the stirring rate of the dissolution medium and hte compression pressure of tablet, did not affect the dissolution of BBL from the tablet.