Disintegrants: effects of interacting variables on the tensile strengths and disintegration times of sulphaguanidine tablets

Abstract

The effects of separately varying the packing fraction ( P), the nature ( N) and concentration ( C) of disintegrants on both the tensile strength and disintegration times of sulphaguanidine tablets are in the orders, respectively, of P > N > N and N > P > N. The combined effects of these variables on the tensile strength are found to be very close to zero and are in the order of N&C > P&N > P&C while those for the disintegration times are significantly removed from zero and the order is P&N > P&C > N&C. Thus, the results indicate that the type and relative proportions of the disintegrants in the formulation have a more complex effect on the disintegration time of the tablets than on their tensile strengths. The ranking of the effects of the various disintegrants on disintegration times is potato starch > alginic acid > methylcellulose.