Abstract
BackgroundAvian pathogenic Escherichia coli (APEC) are the major cause of economic losses in the poultry industry worldwide. Traditionally, antibiotics are used to treat and prevent colibacillosis in broilers. Due to resistance development other ways of preventing/treating the disease have to be found. Therefore during this study the nebulization of low concentrations of hydrogen peroxide (H2O2) was tested in the presence of chickens to lower pathogenicity of APEC.ResultsSignificantly higher total lesion scores and higher E. coli concentrations were found in the spleen of chickens exposed to 2 % H2O2 compared to those exposed to 1 % H2O2 and control chickens which had been exposed to nebulization with distilled water. Higher total lesions scores and E. coli concentrations in the spleen were found in chickens exposed to 1 % H2O2 in comparison to control chickens (not significant).ConclusionH2O2 is rendering animals more prone to APEC infection contraindicating H2O2 nebulization in the presence of chickens.
Highlights
Avian pathogenic Escherichia coli (APEC) are the major cause of economic losses in the poultry industry worldwide
As toxicity is depending on many factors like exposure time, number of exposures and concentration [11] the goal of this study was to test if H2O2 nebulization in the presence of chickens can lower pathogenicity of APEC
To evaluate the hypothesis of a higher total lesion score in infected chickens treated with distilled water (DW) than H2O2, the total lesion scores were analyzed by means of an ordinal logistic regression model
Summary
Avian pathogenic Escherichia coli (APEC) are the major cause of economic losses in the poultry industry worldwide. Due to resistance development other ways of preventing/treating the disease have to be found. Avian pathogenic Escherichia coli (APEC) causes colibacillosis in chickens of all ages, leading yearly to major losses to the poultry industry [1, 2]. Antibiotics have been used for a long time to treat and prevent diseases in chickens; with the consequence of antibiotic resistance development posing a huge threat to the public health worldwide [3] and transfer of virulence and resistance genes to other bacteria [4,5,6]. On conditions safe to the animals, nebulization of hydrogen peroxide (H2O2) in the presence of chickens may possibly lower
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