Abstract

The buccal tablets were formulated using the rate controlling polymers such as carbopol 974 P and Hydroxy propyl methyl cellulose K4M (HPMC K4M) or Sodium alginate in various ratios by D-Optimal design. Numerical optimization technique was applied to find out the best formulation by using the software Design Expert. All the formulations were evaluated and it was found that the carbopol 974P have good bioadhesion property but the HPMC K4M controls the drug release. In vitro drug release and release exponent were considered as dependent variables for optimization. The ideal formulation was undergone in vitro diffusion studies and stability studies.

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